The House of Andriy Melenskyi is a one-and-a-half-storey brick building, plastered and L-shaped in plan. The roof is covered with sheet metal — hipped over the wing facing Kostyantynivska Street and gable over the other wing. The layout is enfilade, typical of late 18th–early 19th-century residential design.

The principal façades, each with five window axes, are executed in the Classical style. The lower tier is rusticated, and the central bay of the main façade on Khoryva Street is accentuated by paired Doric pilasters and a parapet above them. The windows of the lower semi-storey (now bricked up) had keystones, while those of the upper storey were framed with sandriks supported by brackets. Horizontal divisions are articulated by an interfloor cornice and a crowning entablature. The building was constructed in the Classicist style, though the architect remains unknown.

From 1818 to 1833, the house was the residence of Andriy Ivanovych Melenskyi (1766–1833) — the first city architect of Kyiv and the designer of many of its most significant buildings. Beginning in 1799, Melenskyi developed several general plans of Kyiv and proposed the urban redesign of the Podil district after the devastating fire of 1811. His proposals formed the basis for the officially approved plan by St. Petersburg architect William Heste, which Melenskyi subsequently implemented in practice.

He is also credited with the idea of laying out Khreshchatyk Street, which later became Kyiv’s main thoroughfare, symbolizing his lasting influence on the city’s architectural and urban development.